NAD+ supplements, such as Nicotinamide Riboside Chloride
NAD+ is a compound present in every cell in the body, which is involved in many important processes, including energy synthesis, DNA repair, and gene expression. NAD+ levels decrease with age, and this is thought to be associated with increased biological aging and the onset of age-related diseases such as Alzheimer’s.
Animal experiments have demonstrated that supplementation of NAD+ precursors Nicotinamide Mononucleotide and Nicotinamide Riboside restores NAD+ levels and reduces age-related physical deterioration. There’s ample evidence that NAD+ plays a significant role in aging — it’s involved in multiple biological functions and is a central regulator of stress tolerance. NAD+ levels gradually decrease with age, resulting in altered metabolism and increased disease vulnerability. Evidence indicates that supplementation with NAD+ precursors, or inhibition of NAD+ depletion, can enhance metabolic function. While supplementation with NAD+ precursors has been found to delay aging.
TA-65
- Astragalus used 1000’s years in traditional medicines. More recently credited with elongating telomeres and rejuvenating cells. Antiviral properties, immune system stimulant.
- Telomeres are caps at end of DNA strands, that shorten with age. Short telomeres are linked to increased risk of cardiovascular disease and diabetes.
- The enzyme telomerase works by slowing, stopping or reversing shortening telomeres.
- Positive trial results regarding boosting immune response, cardiovascular and metabolic health, improvement in telomere length, AMD reversal.
- May also improve vision, sleep, weight control, increased energy, strength sexual enhancement, skin, thicken hair.
- Licensed as medical food, further studies required regarding long term safety.
Every time one of your cells divides a piece of its’ DNA -called a telomere- is lost. Telomeres have been referred to as the “protective caps” of our chromosomes because they maintain their structure and protect the genes. At conception our telomeres average 15,000 base pairs in length and through cell division they are reduced to 10,000 base pairs by the time we are born. Throughout life we lose 20-60 base pairs per year.
T.A. Sciences
TA-65 is a supplement that can help preserve ‘telomeres’. Telomeres are the caps on the end of chromosomes. As humans age, telomeres degrade — and telomere length is an extremely accurate measure of true age and a good predictor of general health status; while shorter telomeres have been associated with cell ageing and dysfunction.
Glycine
Glycine is one of the three amino acids the body uses to produce glutathione, an effective antioxidant that helps defend the cells from oxidative damage triggered by free radicals. Because glutathione diminishes with age, using glycine or glycine-containing supplements may help the body produce more glutathione and defend cells from oxidative damage.
A study published in Aging Cell revealed that:
Elevated glycine led to a small (4%–6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001). Via Wiley Online Library
Curcumin
Curcumin is the key active compound in turmeric. It has been shown to exhibit powerful anti-aging properties due to its strong antioxidant activities. Cell senescence happens as cells stop dividing. As you mature, senescent cells accumulate, which is thought to intensify aging and disease development. Analysis reveals that curcumin stimulates some proteins, including sirtuins and AMP-activated protein kinase (AMPK), which helps slow cell senescence and enhances longevity. You can improve the consumption of curcumin by using turmeric in recipes or by taking curcumin supplements.
Crocin
Crocin is a yellow carotenoid pigment in saffron, a traditional, expensive spice that is widely used in Indian and Spanish cuisine. Human and animal research have demonstrated that crocin has multiple health benefits, including anti-cancer, anti-inflammatory, anti-anxiety and anti-diabetic effects.
In addition to the properties mentioned above, Crocin has been studied for its ability to function as an anti-aging agent and to guard against age-related cognitive decline. Experiments have shown that crocin helps avoid age-related nerve damage by inhibiting the development of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are chemicals that lead to the ageing process.
7 Most Effective Anti-ageing Supplements
Rapamycin
First licensed more than 20 years ago as an immunosuppressant.
Treats renal transplant patients.
It’s immune-modulating and anti-inflammatory.
Anti-aging doses eliminate hyper-immunity, don’t suppress immunity.
Rapamycin rejuvenates immunity.
More effective at slowing down aging than reversing it. Most effective at the pre-disease, or even pre-pre-disease stages of age-related diseases. Use to extend lifespan rather than treat diseases after diagnoses.
Anti-aging trials by 2006 extensive work from “several” independent studies suggested Rapamycin as an anti-aging drug.
Mild, reversible low platelet count, anaemia and leucopoenia are the most common side effects. Although, for some people platelets reduction is beneficial, some use Aspirin to achieve a platelet reduction.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/
Vitamin C
Wide ranging metabolic functions.
Offers protection from oxidative free-radical damage.
Essential for the production of collagen.
Reduces the wrinkling and sagging of the skin that occurs with aging.
Cell regulator in cancer treatment.
Helps maintain mucous membranes, adrenal hormone production, immune function, including humoral immunity, and phagocytosis.
US RDA for vitamin C recently raised to 90mg for men and 75mg for women, higher for smokers. Trials of 500mg significantly lowered blood pressure.
Daily doses of 500mg in a group followed for an average of 6.3 years saw advanced age-related macular degeneration decrease by 28%.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646595/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695174/
Coenzyme Q10
Our bodies naturally produce, decreases with age.
Supplementation helps prevent:
Brain disorders, heart disease, diabetes, cancer.
It improves insulin sensitivity, slows age-related physical decline, improving quality of life in older adults.
Treats fatigue and cardiovascular issues in over 40’s (World Health.Net). Essential for the heart, helps lower blood pressure.
Available in two different forms ubiquinol easier to absorb. CoQ10 is fat-soluble and absorption is slow. Taking with food increases absorption, absorption rate.
Standard dose 90mg to 200mg/day. Up to 500mg and higher have been trailed without any serious side effects; trails for Parkinson’s Disease treatment found safe, well tolerated at dosages of up to 1200mg/day.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695174/
https://www.healthline.com/nutrition/anti-aging-supplements#4.-CoQ10
https://pubmed.ncbi.nlm.nih.gov/12374491/
Collagen
Product tested ELASTEN, Quiris Healthcare
Collagen is the decisive protein that maintains skin structure. We produce less as we age. The appearance of our skin largely depends on the homeostasis of the dermal extracellular matrix, defined primarily by collagen and similar fibers. Collagen taken orally reaches and stimulates deep layers of the skin.
After a three month trial of 72 women, tests showed significantly improvement of skin hydration, elasticity, density and roughness. Skin appearance was significantly improved.
There are no side effects and proven to be well tolerated and safe.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835901/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041324/
Curcumin
Chemical Name: Diferuloylmethane
Elongates the lifespan of model organisms.
Curcumin alleviates ageing symptoms, postpones progression of senscense involved age-related diseases. Elimination of senescent cells significantly improves quality of life.
Has anti-inflammatory, antioxidant properties, mitigate symptoms of ageing.
Serves as a neuro-protective agent, helps prevent muscle fatigue.
Tests prove reduces symptoms of age-related diseases: Atherosclerosis, diabetes and cancer.
In trials on mice they looked younger and were fitter.
Curcumin is poorly absorbed by intestinal cells, rapidly metabolized.
No side effects, safe in even extremely high dosage.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429134/
Selenium
An essential trace element, correct dosage is essential for optimization.
US recommended daily allowance (RDA) is 0.055mg/day.
Selenium is essential for the brain regulating thyroid function, and helping the immune system, has an important role in preventing cellular damage induced by free radicals.
Selenium can help protect us from various cancers, is said to help protect the brain from Alzheimer’s.
Once cancer is established Selenium protects the cancer cells.
Too high dose can increase risks for melanoma, oropharyngeal, lymphoids and urinary cancers. High excess can increase risk of type II diabetes.
Trials show supplement useful for those with deficit.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213372/#B3-nutrients-10-01466
